Trefoil factor 1 suppression of E-CADHERIN enhances prostate carcinoma cell invasiveness and metastasis

被引：18

作者：

Bougen, N. M. ^{[1
]}

Amiry, N. ^{[2
]}

Yuan, Y. ^{[3
,4
]}

Kong, X. J. ^{[3
,4
]}

Pandey, V. ^{[1
]}

Vidal, L. J. P. ^{[2
]}

Perry, J. K. ^{[2
]}

Zhu, T. ^{[3
,4
]}

Lobie, P. E. ^{[1
,5
,6
]}

机构：

[1] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore

[2] Univ Auckland, Liggins Inst, Auckland 1, New Zealand

[3] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China

[4] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China

[5] Natl Univ Singapore, Dept Pharmacol, Singapore 117599, Singapore

[6] Natl Univ Hlth Syst, Natl Canc Inst Singapore, Singapore, Singapore

来源：

CANCER LETTERS | 2013年 / 332卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Trefoil factor 1; Prostate cancer; Epithelial-to-mesenchymal transition; Metastasis; EPIDERMAL-GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITIONS; GENE-EXPRESSION PROFILES; HUMAN MAMMARY-CARCINOMA; CANCER BONE METASTASIS; EGF RECEPTOR; EPIGENETIC REGULATION; SIGNALING PATHWAYS; ANDROGEN RECEPTOR; PROTEIN TFF1;

D O I：

10.1016/j.canlet.2012.12.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Metastasis is the primary mediator of prostate cancer (PCA) lethality and poses a significant clinical obstacle. The identification of factors involved in the metastasis of PCA is imperative. We demonstrate herein that trefoil factor 1 (TFF1) promotes PCA cell migration and invasion in vitro and metastasis in vivo. The capacity of TFF1 to enhance cell migration/invasion is mediated by transcriptional repression of E-CADHERIN. Consideration of targeted inhibition of TFF1 to prevent metastasis of prostate carcinoma is warranted. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：19 / 29

页数：11

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