NKG2D ligands:: key targets of the immune response

被引：204

作者：

Gonzalez, Segundo ^{[2
]}

Lopez-Soto, Alejandro ^{[2
]}

Suarez-Alvarez, Beatriz ^{[1
]}

Lopez-Vazquez, Antonio ^{[1
]}

Lopez-Larrea, Carlos ^{[1
,3
]}

机构：

[1] Hosp Univ Cent Asturias, Dept Immunol, Oviedo 33006, Spain

[2] Univ Oviedo, Dept Funct Biol, IUOPA, E-33006 Oviedo, Spain

[3] Fdn Renal Inigo Alvarez Toledo, Madrid 28003, Spain

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 08期

关键词：

D O I：

10.1016/j.it.2008.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKG2D is an activating receptor expressed by NK and T cells. NKG2D ligands show a restricted expression in normal tissues, but they are frequently overexpressed in cancer and infected cells. The binding of NKG2D to its ligands activates NK and T cells and promotes cytotoxic lysis of the cells expressing these molecules. The mechanisms involved in the expression of the ligands of NKG2D play a key role in the recognition of stressed cells by the immune system and represent a promising therapeutic target for improving the immune response against cancer or autoimmune disease. In this review, we analyse the recent advances in understanding the regulation of NKG2D ligand expression and their therapeutic implications.

引用

页码：397 / 403

页数：7

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