Cloning and characterization of cDNAs for novel proteins with glutamic acid-proline dipeptide tandem repeats

被引：40

作者：

Geertman, R ^{[1
]}

McMahon, A ^{[1
]}

Sabban, EL ^{[1
]}

机构：

[1] NEW YORK MED COLL, DEPT BIOCHEM & MOLEC BIOL, VALHALLA, NY 10595 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1996年 / 1306卷 / 2-3期

关键词：

dipeptide repeat; nucleotide sequence; procyclin; brain; muscle;

D O I：

10.1016/0167-4781(96)00036-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cDNAs with identical 3' sequences containing a hexanucleotide repeat -(GAGCCG)(9)- were isolated from rat pheochromocytoma and brain cDNA libraries. The cDNA with the longest open reading frame codes for a protein of 24.6 kDa containing a 16-fold -(Glu-Pro)-dipeptide repeat within a glutamate and proline rich region at its deduced C-terminus. cDNAs with the identical 3' sequence and a divergent 5' sequence were isolated from a rat skeletal muscle cDNA library. The latter are predicted to code for a protein of 15.5 kDa with a C-terminal repetitive domain identical to that in the pheochromocytoma and brain cDNAs. The cDNAs recognize a 1.8 kb mRNA species present in a variety of tissues, being particularly abundant in cardiac and skeletal muscle.

引用

页码：147 / 152

页数：6

共 24 条

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