A short route to functionalized imidazo[4,5-c]carbazoles.: Synthesis of the first example of the imidazo[4,5-c]β-carboline ring system

被引：13

作者：

Achab, S ^{[1
]}

Diker, K ^{[1
]}

Potier, P ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(01)01915-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic route to functionalized imidazo[4,5-c]carbazoles (4) via intramolecular electrocyclization of indolo-1,3,5-hexatriene system (3a) is described. Thermally induced ring-closure of 2-ethylcarboxylate-(4-amino-5-imidazolyl)-3-indole (3d) led to the previously unknown imidazo[4,5-c]beta -carboline ring system (5). These heterocycles were efficiently converted into analogs of both the marine cytotoxic agents grossularines-1 and -2 (1) and the antimicrobial alkaloid eudistomin U (2). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8825 / 8828

页数：4

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