Advantages of Phosphodiesterase Type 5 Inhibitors in the Management of Glucose Metabolism Disorders: A Clinical and Translational Issue

被引：13

作者：

Antinozzi, Cristina ^{[1
]}

Sgro, Paolo ^{[1
]}

Di Luigi, Luigi ^{[1
]}

机构：

[1] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, Unit Endocrinol, I-00135 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2020年 / 2020卷

关键词：

ACTIVATED PROTEIN-KINASE; IMPROVES INSULIN SENSITIVITY; PDE5; INHIBITORS; NITRIC-OXIDE; SKELETAL-MUSCLE; ENDOTHELIAL FUNCTION; ERECTILE DYSFUNCTION; DIABETES-MELLITUS; AMP KINASE; SILDENAFIL;

D O I：

10.1155/2020/7078108

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Among metabolic diseases, carbohydrate metabolism disorders are the most widespread. The most common glucose pathological conditions are acquired and may increase the risk of type 2 diabetes, obesity, heart diseases, stroke, and kidney insufficiency. Phosphodiesterase type 5 inhibitors (PDE5i) have long been used as an effective therapeutic option for the treatment of erectile dysfunction (ED). Different studies have demonstrated that PDE5i, by sensitizing insulin target tissues to insulin, play an important role in controlling the action of insulin and glucose metabolism, highlighting the protective action of these drugs against metabolic diseases. In this review, we report the latest knowledge about the role of PDE5i in the metabolic diseases of insulin resistance and type 2 diabetes, highlighting clinical aspects and potential treatment approaches. Although various encouraging data are available, further in vivo and in vitro studies are required to elucidate the mechanism of action and their clinical application in humans.

引用

页数：8

共 84 条

[21]

Diabetes is a vascular disease: the role of endothelial dysfunction in pathophysiology of cardiovascular disease in diabetes [J].

Deedwania, PC .

CARDIOLOGY CLINICS, 2004, 22 (04) :505-+

[22]

Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)α1-specific activity and glucose transport in human skeletal muscle [J].

Deshmukh, A. S. ;

Long, Y. C. ;

Barbosa, T. de Castro ;

Karlsson, H. K. R. ;

Glund, S. ;

Zavadoski, W. J. ;

Gibbs, E. M. ;

Koistinen, H. A. ;

Wallberg-Henriksson, H. ;

Zierath, J. R. .

DIABETOLOGIA, 2010, 53 (06) :1142-1150

[23]

Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes [J].

Desouza, C ;

Parulkar, A ;

Lumpkin, D ;

Akers, D ;

Fonseca, VA .

DIABETES CARE, 2002, 25 (08) :1336-1339

[24]

Phosphodiesterase Type 5 Inhibitor Sildenafil Decreases the Proinflammatory Chemokine CXCL10 in Human Cardiomyocytes and in Subjects with Diabetic Cardiomyopathy [J].

Di Luigi, Luigi ;

Corinaldesi, Clarissa ;

Colletti, Marta ;

Scolletta, Sabino ;

Antinozzi, Cristina ;

Vannelli, Gabriella B. ;

Giannetta, Elisa ;

Gianfrilli, Daniele ;

Isidori, Andrea M. ;

Migliaccio, Silvia ;

Poerio, Noemi ;

Fraziano, Maurizio ;

Lenzi, Andrea ;

Crescioli, Clara .

INFLAMMATION, 2016, 39 (03) :1238-1252

[25]

PDE-5 Inhibitors: Clinical Points [J].

Doumas, Michael ;

Lazaridis, Antonios ;

Katsiki, Niki ;

Athyros, Vasilios .

CURRENT DRUG TARGETS, 2015, 16 (05) :420-426

[26]

Cardiomyopathy Associated with Diabetes: The Central Role of the Cardiomyocyte [J].

Filardi, Tiziana ;

Ghinassi, Barbara ;

Di Baldassarre, Angela ;

Tanzilli, Gaetano ;

Morano, Susanna ;

Lenzi, Andrea ;

Basili, Stefania ;

Crescioli, Clara .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (13)

[27]

PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial [J].

Fiore, Daniela ;

Gianfrilli, Daniele ;

Giannetta, Elisa ;

Galea, Nicola ;

Panio, Giuseppe ;

di Dato, Carla ;

Pofi, Riccardo ;

Pozza, Carlotta ;

Sbardella, Emilia ;

Carbone, Iacopo ;

Naro, Fabio ;

Lenzi, Andrea ;

Venneri, Mary A. ;

Isidori, Andrea M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (04) :1525-1534

[28]

Reactive Oxygen Species in Metabolic and Inflammatory Signaling [J].

Forrester, Steven J. ;

Kikuchi, Daniel S. ;

Hernandes, Marina S. ;

Xu, Qian ;

Griendling, Kathy K. .

CIRCULATION RESEARCH, 2018, 122 (06) :877-+

[29]

PDE5 inhibitors: targeting erectile dysfunction in diabetics [J].

Francis, Sharron H. ;

Corbin, Jackie D. .

CURRENT OPINION IN PHARMACOLOGY, 2011, 11 (06) :683-688

[30]

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action [J].

Francis, Sharron H. ;

Busch, Jennifer L. ;

Corbin, Jackie D. .

PHARMACOLOGICAL REVIEWS, 2010, 62 (03) :525-563

← 1 2 3 4 5 6 7 8 9 →