Osteoarthritic cartilage loses its ability to remain avascular

被引:47
作者
Fenwick, SA
Gregg, PJ
Rooney, P
机构
[1] Addenbrookes Hosp, Rheumatol Res Unit, Cambridge CB2 2QQ, England
[2] Univ Leicester, Glenfield Hosp NHS Trust, Dept Orthopaed Surg, Leicester LE3 9QP, Leics, England
[3] Univ Newcastle Upon Tyne, Sch Med, Dept Surg, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
关键词
osteoarthritis; cartilage; vascularization; CAM graft;
D O I
10.1053/joca.1998.0238
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Objective: To determine whether human osteoarthritic (OA) cartilage loses its ability to remain avascular when placed into the in-vivo model of angiogenesis, the chick embryo chorio-allantoic membrane (CAM), and to determine specific changes that occur in the cartilage matrix when the cartilage is exposed to an active vasculature. Design: Articular cartilage from GA and non-GA joints was grafted onto the CAM for up to 5 days before fixing and processing for histological, histochemical and immunological examination for specific changes in proteoglycan and collagen. Results: OA cartilage, but not non-GA cartilage, showed invasion of its matrix by blood vessels from the CAM to various extents. Associated with these blood vessels was a loss of staining for proteoglycans and cartilage specific glycosaminoglycans (GAG). A deposition of collagen types I and X was also visualized around the invasive vessels. Conclusions: OA cartilage loses or has already lost its ability to remain avascular when placed onto the chick CAM. Changes occur in the matrix around the invasive blood vessels, specifically a loss of proteoglycan and GAG, and the deposition of new collagen types, notably I and X. (C) 1999 OsteoArthritis Research Society International.
引用
收藏
页码:441 / 452
页数:12
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