Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold-exposed rats

被引：11

作者：

Jakus, PB ^{[1
]}

Sipos, K ^{[1
]}

Kispal, G ^{[1
]}

Sandor, A ^{[1
]}

机构：

[1] Univ Pecs, Fac Med, Dept Biochem, H-7624 Pecs, Hungary

来源：

FEBS LETTERS | 2002年 / 519卷 / 1-3期

关键词：

uncoupling protein; brown adipose tissue; glucose transporter 4;

D O I：

10.1016/S0014-5793(02)02707-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Earlier we reported a 14-fold increase of glycogen in the brown adipose tissue (BAT) in rats when the animals were placed back from cold to neutral temperature. To elucidate the mechanism, here we compared the level of glucose transporter 4 (GLUT4) protein, uncoupling protein (UCP) 1 and UCP3 mRNA and protein expressions in the BAT under the same conditions. We found that the increased GLUT4 level in cold was maintained during the reacclimation. After 1 week cold exposure the mRNA and protein content of UCP1 increased parallel, while the protein level of UCP3 decreased, contrary to its own mRNA level. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：210 / 214

页数：5

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