Differential regulation of uncoupling protein-2 and uncoupling protein-3 gene expression in brown adipose tissue during development and cold exposure

被引：54

作者：

Carmona, MC ^{[1
]}

Valmaseda, A ^{[1
]}

Brun, S ^{[1
]}

Viñas, O ^{[1
]}

Mampel, T ^{[1
]}

Iglesias, R ^{[1
]}

Giralt, M ^{[1
]}

Villarroya, F ^{[1
]}

机构：

[1] Univ Barcelona, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 243卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.8088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of the two novel uncoupling proteins genes, UCP2 and UCP3, is differentially regulated during prenatal maturation of brown adipose tissue in the mouse. UCP2 gene is expressed early in prenatal development, when neither UCP1 nor UCP3 gene expression yet occurs. UCP3 mRNA is absent at any stage of fetal life; it appears suddenly at birth and reaches adult levels in a few hours. UCP2 mRNA increased after birth but more slowly than UCP3 and UCP1 mRNA. Short-time exposure of adult mice to cold caused a rise in UCP2 or UCP1 mRNA levels but not in that of UCP3. The postnatal rise in UCP2 gene expression appears to be a response to the thermic stress associated with birth, similarly to UCP1, whereas different biological signals may be responsible for the surge in UCP3 gene expression at birth. (C) 1998 Academic Press.

引用

页码：224 / 228

页数：5

共 26 条

[1] Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells [J].

Aubert, J ;

Champigny, O ;

SaintMarc, P ;

Negrel, R ;

Collins, S ;

Ricquier, D ;

Ailhaud, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) :606-611

[2] ULTRASTRUCTURAL CHANGES IN CHONDRIOME DURING PERINATAL DEVELOPMENT IN BROWN ADIPOSE TISSUE OF RATS [J].

BARNARD, T ;

LINDBERG, O .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1969, 29 (3-4) :293-&

[3] INTRACELLULAR CONVERSION OF THYROXINE TO TRIIODOTHYRONINE IS REQUIRED FOR THE OPTIMAL THERMOGENIC FUNCTION OF BROWN ADIPOSE-TISSUE [J].

BIANCO, AC ;

SILVA, JE .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) :295-300

[4] Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold [J].

Boss, O ;

Samec, S ;

Dulloo, A ;

Seydoux, J ;

Muzzin, P ;

Giacobino, JP .

FEBS LETTERS, 1997, 412 (01) :111-114

[5] Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression [J].

Boss, O ;

Samec, S ;

PaoloniGiacobino, A ;

Rossier, C ;

Dulloo, A ;

Seydoux, J ;

Muzzin, P ;

Giacobino, JP .

FEBS LETTERS, 1997, 408 (01) :39-42

[6] MOLECULAR APPROACH TO THERMOGENESIS IN BROWN ADIPOSE-TISSUE - CDNA CLONING OF THE MITOCHONDRIAL UNCOUPLING PROTEIN [J].

BOUILLAUD, F ;

RICQUIER, D ;

THIBAULT, J ;

WEISSENBACH, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (02) :445-448

[7]

BUCKOWIECKI L, 1986, AM J PHYSIOL, V250, pC880

[8]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[9] Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese [J].

Enerback, S ;

Jacobsson, A ;

Simpson, EM ;

Guerra, C ;

Yamashita, H ;

Harper, ME ;

Kozak, LP .

NATURE, 1997, 387 (6628) :90-94

[10] REDUCTION OF BACKGROUND PROBLEMS IN NONRADIOACTIVE NORTHERN AND SOUTHERN BLOT ANALYSES ENABLES HIGHER SENSITIVITY THAN P-32 BASED HYBRIDIZATIONS [J].

ENGLERBLUM, G ;

MEIER, M ;

FRANK, J ;

MULLER, GA .

ANALYTICAL BIOCHEMISTRY, 1993, 210 (02) :235-244

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