Normal peroxisome development from vesicles induced by truncated Hansenula polymorpha Pex3p

被引：43

作者：

Faber, KN ^{[1
]}

Haan, GJ ^{[1
]}

Baerends, RJS ^{[1
]}

Kram, AM ^{[1
]}

Veenhuis, M ^{[1
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, GBB, NL-9750 AA Haren, Netherlands

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2002年 / 277卷 / 13期

关键词：

D O I：

10.1074/jbc.M112347200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show that the synthesis of the N-terminal 50 amino acids of Pex3p (Pex3p(1-50)) in Hansenula polymorpha pex3 cells is associated with the formation of vesicular membrane structures. Biochemical and ultrastructural findings suggest that the nuclear membrane is the donor membrane compartment of these vesicles. These structures also contain Pex14p and can develop into functional peroxisomes after subsequent reintroduction of the full-length Pex3p protein. We discuss the significance of this finding in relation to peroxisome reintroduction, e.g. in case peroxisomes are lost due to failure in inheritance.

引用

页码：11026 / 11033

页数：8

共 44 条

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