Rho GEFs and Cancer: Linking Gene Expression and Metastatic Dissemination

被引：52

作者：

Barrio-Real, Laura ^{[1
]}

Kazanietz, Marcelo G. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

来源：

SCIENCE SIGNALING | 2012年 / 5卷 / 244期

关键词：

NUCLEOTIDE EXCHANGE FACTOR; SIGNAL TRANSDUCER VAV1; RAC ACTIVATOR TIAM1; BREAST-CANCER; CELL-PROLIFERATION; MELANOMA; PROSTATE; FAMILY; OVEREXPRESSION; MUTATIONS;

D O I：

10.1126/scisignal.2003543

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Guanine nucleotide exchange factors (GEFs) that promote GTP loading onto the guanosine triphosphatases (GTPases) Rho and Rac are prominent players in cancer progression. Recent studies have highlighted the relevance of several GEFs, including the phosphatidylinositol 3,4,5-trisphosphate Rac exchangers P-Rex1 and P-Rex2a, in breast tumorigenesis. New evidence suggests that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis. The identification of a Vav-regulated transcriptome and Vav-related genes that control specific steps of metastatic dissemination of breast cancer cells to the lungs highlights the complexities of the signaling networks regulated by Rho/Rac GTPases and may lead to novel therapeutic targets.

引用

页数：5

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