Bcr-Abl variants:: biological and clinical aspects

被引：86

作者：

Advani, AS

Pendergast, AM

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, LSRC, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Hematol & Oncol, Durham, NC 27710 USA

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 08期

关键词：

Philadelphia chromosome; Bcr-Abl; acute lymphocytic leukemia; chronic myelogenous leukemia; chronic neutrophilic leukemia;

D O I：

10.1016/S0145-2126(01)00197-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bcr-Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-oncogene. Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias. Examination of the signaling pathways differentially regulated by the Bcr-Abl proteins will help us gain better insight into Bcr-Abl mediated leukemogenesis. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：713 / 720

页数：8

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