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Bcr-Abl variants:: biological and clinical aspects

被引：86
作者：
Advani, AS
Pendergast, AM
机构：
[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, LSRC, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Hematol & Oncol, Durham, NC 27710 USA
来源：
LEUKEMIA RESEARCH | 2002年 / 26卷 / 08期
关键词：
Philadelphia chromosome; Bcr-Abl; acute lymphocytic leukemia; chronic myelogenous leukemia; chronic neutrophilic leukemia;
D O I：
10.1016/S0145-2126(01)00197-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bcr-Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-oncogene. Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias. Examination of the signaling pathways differentially regulated by the Bcr-Abl proteins will help us gain better insight into Bcr-Abl mediated leukemogenesis. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：713 / 720
页数：8
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