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Bcr-Abl variants:: biological and clinical aspects

被引：86
作者：
Advani, AS
Pendergast, AM
机构：
[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, LSRC, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Hematol & Oncol, Durham, NC 27710 USA
来源：
LEUKEMIA RESEARCH | 2002年 / 26卷 / 08期
关键词：
Philadelphia chromosome; Bcr-Abl; acute lymphocytic leukemia; chronic myelogenous leukemia; chronic neutrophilic leukemia;
D O I：
10.1016/S0145-2126(01)00197-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bcr-Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-oncogene. Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias. Examination of the signaling pathways differentially regulated by the Bcr-Abl proteins will help us gain better insight into Bcr-Abl mediated leukemogenesis. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：713 / 720
页数：8
相关论文
共 148 条
[61]   Mouse disabled (mDab1): A Src binding protein implicated in neuronal development [J].
Howell, BW ;
Gertler, FB ;
Cooper, JA .
EMBO JOURNAL, 1997, 16 (01) :121-132
[62]   P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members [J].
Ilaria, RL ;
VanEtten, RA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (49) :31704-31710
[63]  
INOKUCHI K, 1991, BLOOD, V78, P3125
[64]   Novel therapies for chronic myelogenous leukemia [J].
Jahagirdar, BN ;
Miller, JS ;
Shet, A ;
Verfaillie, CM .
EXPERIMENTAL HEMATOLOGY, 2001, 29 (05) :543-556
[65]   Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation:: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity [J].
Jiang, YH ;
Zhao, RCH ;
Verfaillie, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10538-10543
[66]   CYTOGENETIC STUDIES OF HEMATOPOIETIC COLONIES FROM PATIENTS WITH AN INITIAL DIAGNOSIS OF ACUTE LYMPHOBLASTIC-LEUKEMIA [J].
KALOUSEK, DK ;
DUBE, ID ;
EAVES, CJ ;
EAVES, AC .
BRITISH JOURNAL OF HAEMATOLOGY, 1988, 70 (01) :5-11
[67]  
KANTARJIAN HM, 1993, BLOOD, V82, P691
[68]   SIGNIFICANCE OF THE P210 VERSUS P190 MOLECULAR ABNORMALITIES IN ADULTS WITH PHILADELPHIA CHROMOSOME-POSITIVE ACUTE-LEUKEMIA [J].
KANTARJIAN, HM ;
TALPAZ, M ;
DHINGRA, K ;
ESTEY, E ;
KEATING, MJ ;
KU, S ;
TRUJILLO, J ;
HUH, Y ;
STASS, S ;
KURZROCK, R .
BLOOD, 1991, 78 (09) :2411-2418
[69]   DEFINITION OF THE ACCELERATED PHASE OF CHRONIC MYELOGENOUS LEUKEMIA [J].
KANTARJIAN, HM ;
TALPAZ, M .
JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (01) :180-181
[70]  
KANTARJIAN HM, 1988, CANCER, V61, P1441, DOI 10.1002/1097-0142(19880401)61:7<1441::AID-CNCR2820610727>3.0.CO
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