The Plane Facts of PCP in the CNS

被引：52

作者：

Goodrich, Lisa V. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

NEURON | 2008年 / 60卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2008.09.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Planar cell polarity (PCP) pathways have been defined by their ability to direct the development of obviously polarized cellular architectures. Recent studies indicate that PCP pathways also regulate aspects of cell morphology that are not restricted to the plane of the epithelium. In the developing nervous system, PCP-mediated changes in the cytoskeleton are fundamental to neuronal migration, neuronal polarity, axon guidance, and dendritic arborization, highlighting the importance of "planar polarity" genes for defining the shape of a neuron in all dimensions.

引用

页码：9 / 16

页数：8

共 61 条

[1] Mathematical modeling of planar cell polarity to understand domineering nonautonomy [J].

Amonlirdviman, K ;

Khare, NA ;

Tree, DRP ;

Chen, WS ;

Axelrod, JD ;

Tomlin, CJ .

SCIENCE, 2005, 307 (5708) :423-426

[2] Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling [J].

Chen, Wei-Shen ;

Antic, Dragana ;

Matis, Maja ;

Logan, Catriona Y. ;

Povelones, Michael ;

Anderson, Graham A. ;

Nusse, Roel ;

Axelrod, Jeffrey D. .

CELL, 2008, 133 (06) :1093-1105

[3] Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype [J].

Ciani, L ;

Patel, A ;

Allen, ND ;

Ffrench-Constant, C .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (10) :3575-3582

[4] Planar cell polarity signalling couples cell division and morphogenesis during neurulation [J].

Ciruna, B ;

Jenny, A ;

Lee, D ;

Mlodzik, M ;

Schier, AF .

NATURE, 2006, 439 (7073) :220-224

[5] The genetic basis of mammalian neurulation [J].

Copp, AJ ;

Greene, NDE ;

Murdoch, JN .

NATURE REVIEWS GENETICS, 2003, 4 (10) :784-793

[6] Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse [J].

Curtin, JA ;

Quint, E ;

Tsipouri, V ;

Arkell, RM ;

Cattanach, B ;

Copp, AJ ;

Henderson, DJ ;

Spurr, N ;

Stanier, P ;

Fisher, EM ;

Nolan, PM ;

Steel, KP ;

Brown, SDM ;

Gray, IC ;

Murdoch, JN .

CURRENT BIOLOGY, 2003, 13 (13) :1129-1133

[7] Asymmetric distribution of Prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear [J].

Deans, Michael R. ;

Antic, Dragana ;

Suyama, Kaye ;

Scott, Matthew P. ;

Axelrod, Jeffrey D. ;

Goodrich, Lisa V. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (12) :3139-3147

[8] The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance [J].

Emoto, Kazuo ;

Parrish, Jay Z. ;

Jan, Lily Yeh ;

Jan, Yuh-Nung .

NATURE, 2006, 443 (7108) :210-213

[9] Planar polarity from flies to vertebrates [J].

Fanto, M ;

McNeill, H .

JOURNAL OF CELL SCIENCE, 2004, 117 (04) :527-533

[10] The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor [J].

Fanto, M ;

Clayton, L ;

Meredith, J ;

Hardiman, K ;

Charroux, B ;

Kerridge, S ;

McNeill, H .

DEVELOPMENT, 2003, 130 (04) :763-774

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