QUANTIFICATION OF CEREBROSPINAL FLUID FERRITIN AS A BIOMARKER FOR CNS MALIGNANT INFILTRATION

被引：11

作者：

de Almeida, Sergio Monteiro ^{[1
]}

da Cunha, Dione Sosnitzki ^{[1
]}

Yamada, Edna ^{[1
]}

Doi, Elvira Missako ^{[1
]}

Ono, Margaret ^{[1
]}

机构：

[1] UFPR, Hosp Clin, Secao Virol, Setor Anal Clin,Clin Pathol Lab, BR-80060240 Curitiba, Parana, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2008年 / 66卷 / 3B期

关键词：

cerebrospinal fluid; ferritin; central nervous system; malignant cells; CNS neoplasm; CNS tumors; bacterial meningitis;

D O I：

10.1590/S0004-282X2008000500022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplasic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean +/- SD) in the group with neoplasic cells in the CSF was 42.8 +/- 49.7 ng/mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration.

引用

页码：720 / 724

页数：5

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