PtCl4-Catalyzed Cyclization Reaction of β-Allenols in the Presence of Indoles

被引：40

作者：

Kong, Wangqing ^{[1
]}

Cui, Jie ^{[2
]}

Yu, Yihua ^{[2
]}

Chen, Guofei ^{[1
]}

Fu, Chunling ^{[1
]}

Ma, Shengming ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synth, Hangzhou 310027, Zhejiang, Peoples R China

[2] E China Normal Univ, Dept Phys, Shanghai Key Lab Funct Magnet Resonance Imaging, Shanghai 200062, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

基金：

中国国家自然科学基金;

关键词：

PD(II)-CATALYZED COUPLING-CYCLIZATION; GOLD-CATALYZED CYCLOISOMERIZATION; FRIEDEL-CRAFTS REACTION; EFFICIENT SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; 2,3-ALLENOIC ACIDS; ARYL IODIDES; NUCLEOPHILIC-SUBSTITUTION; MICHAEL ADDITION;

D O I：

10.1021/ol802838v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly regioselective PtCl4-catalyzed reaction of indoles with beta-allenols in THF at room temperature afforded indole derivatives containing a six-membered ether ring at the 3-position in moderate isolated yields. On the basis of a D-labeling experiment, a mechanistic rationale was proposed.

引用

页码：1213 / 1216

页数：4

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