PtCl4-Catalyzed Cyclization Reaction of β-Allenols in the Presence of Indoles

被引:40
作者
Kong, Wangqing [1 ]
Cui, Jie [2 ]
Yu, Yihua [2 ]
Chen, Guofei [1 ]
Fu, Chunling [1 ]
Ma, Shengming [1 ]
机构
[1] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synth, Hangzhou 310027, Zhejiang, Peoples R China
[2] E China Normal Univ, Dept Phys, Shanghai Key Lab Funct Magnet Resonance Imaging, Shanghai 200062, Peoples R China
基金
中国国家自然科学基金;
关键词
PD(II)-CATALYZED COUPLING-CYCLIZATION; GOLD-CATALYZED CYCLOISOMERIZATION; FRIEDEL-CRAFTS REACTION; EFFICIENT SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; 2,3-ALLENOIC ACIDS; ARYL IODIDES; NUCLEOPHILIC-SUBSTITUTION; MICHAEL ADDITION;
D O I
10.1021/ol802838v
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The highly regioselective PtCl4-catalyzed reaction of indoles with beta-allenols in THF at room temperature afforded indole derivatives containing a six-membered ether ring at the 3-position in moderate isolated yields. On the basis of a D-labeling experiment, a mechanistic rationale was proposed.
引用
收藏
页码:1213 / 1216
页数:4
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