Pfs 16 pivotal role in Plasmodium falciparum gametocytogenesis: A potential antiplasmodial drug target

被引：14

作者：

Berry, Antoine ^{[1
]}

Deymier, Caroline ^{[1
]}

Sertorio, Mathieu ^{[1
]}

Witkowski, Benoit ^{[1
,2
]}

Benoit-Vical, Francoise ^{[1
,2
]}

机构：

[1] CHU Toulouse, Serv Parasitol Mycol, F-31059 Toulouse 9, France

[2] CNRS, Chim Coordinat Lab, F-31077 Toulouse, France

来源：

EXPERIMENTAL PARASITOLOGY | 2009年 / 121卷 / 02期

关键词：

Plasmodium falciparum; Gametocytes; Pfs; 16; Drug evaluation; MALARIA PARASITE; IN-VITRO; CLONED LINES; EXPRESSION; GAMETOCYTES; INFECTIVITY; CHLOROQUINE; INVITRO;

D O I：

10.1016/j.exppara.2008.10.010

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Mature gametocytes, the sexual stage of Plasmodium falciparum, ensure the continued transmission of malaria from the human host to the mosquito vector. Even if gametocytes are not implicated in the malaria physiopathology it is crucial to the spread of malaria. Gametocytes are to be a key target for drugs used against Plasmodium in public health. The expression levels of 4 sexual-stage specific genes, Pfs 16, Pfs 25, Pfg 27and S 18S rRNA, during gametocytogenesis of various P. falciparum strains were analyzed by a real time PCR assay. The strains showed different capacities to produce mature gametocytes and in parallel different patterns of sexual gene expression. There was a correlation only between Pfs 16 cDNA overexpression in the first 48 h of the culture and the production of mature gametocytes. Pfs 16 is an early marker of the development of mature gametocytes in cultures and is therefore a potential target for new antimalarial drugs. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：189 / 192

页数：4

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