Signal transduction: IMPlications for Ras-dependent ERK signaling

被引：50

作者：

Ory, S ^{[1
]}

Morrison, DK ^{[1
]}

机构：

[1] NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.cub.2004.03.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.

引用

页码：R277 / R278

页数：2

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