Signal transduction: IMPlications for Ras-dependent ERK signaling

被引:50
作者
Ory, S [1 ]
Morrison, DK [1 ]
机构
[1] NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA
关键词
D O I
10.1016/j.cub.2004.03.023
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.
引用
收藏
页码:R277 / R278
页数:2
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