Signal transduction: IMPlications for Ras-dependent ERK signaling

被引：50

作者：

Ory, S ^{[1
]}

Morrison, DK ^{[1
]}

机构：

[1] NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.cub.2004.03.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.

引用

页码：R277 / R278

页数：2

共 16 条

[11] Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 [J].

Sasaki, A ;

Taketomi, T ;

Kato, R ;

Saeki, K ;

Nonami, A ;

Sasaki, M ;

Kuriyama, M ;

Saito, N ;

Shibuya, M ;

Yoshimura, A .

NATURE CELL BIOLOGY, 2003, 5 (05) :427-432

[12]

Stewart S, 1999, MOL CELL BIOL, V19, P5523

[13] Increasing complexity of the Ras signaling pathway [J].

Vojtek, AB ;

Der, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :19925-19928

[14] Spred is a Sprouty-related suppressor of Ras signalling [J].

Wakioka, T ;

Sasaki, A ;

Kato, R ;

Shouda, T ;

Matsumoto, A ;

Miyoshi, K ;

Tsuneoka, M ;

Komiya, S ;

Baron, R ;

Yoshimura, A .

NATURE, 2001, 412 (6847) :647-651

[15] The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins [J].

Wang, Y ;

Waldron, RT ;

Dhaka, A ;

Patel, A ;

Riley, MM ;

Rozengurt, E ;

Colicelli, J .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (03) :916-926

[16] Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the Raf kinase inhibitor protein [J].

Yeung, K ;

Janosch, P ;

McFerran, B ;

Rose, DW ;

Mischak, H ;

Sedivy, JM ;

Kolch, W .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (09) :3079-3085

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