Immature dendritic cell exosomes suppress experimental autoimmune myasthenia gravis

被引：38

作者：

Bu, Ning ^{[1
]}

Wu, Hai-Qin ^{[1
]}

Zhang, Gui-Lian ^{[1
]}

Zhan, Shu-Qin ^{[1
]}

Zhang, Ru ^{[1
]}

Fan, Qing-Yu ^{[1
]}

Li, Yan-Ling ^{[1
]}

Zhai, Yue-Fan ^{[1
]}

Ren, Hong-Wei ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 2, Xian 710004, Shaanxi, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 285卷

关键词：

Immature dendritic cell (iMDC); Exosomes; Experimental autoimmune myasthenia gravis (EAMG); ACETYLCHOLINE-RECEPTOR; MONOCLONAL-ANTIBODIES; ANTIGEN PRESENTATION; T-CELLS; IMMUNITY; MICE;

D O I：

10.1016/j.jneuroim.2015.04.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immature dendritic cell-derived exosomes (iMDEX) display a certain degree of immunosuppressive activity in autoimmune diseases. However, the role of iMDEX in experimental autoimmune myasthenia gravis (EAMG) is still unclear. Therefore, we tested the effects of mouse bone marrow (BM)-derived iMDEX on tolerance induction in a mouse model of EAMG. In this study, we found that the CELLine culture system produced more exosomes, the morphology and phenotype of these exosomes were found to be identical when compared with traditional cell culture. And, iMDEX((1000)) ameliorated the progression of EAMG by reducing AChR-reactive lymphocyte proliferation, AChR antibody levels and pro-inflammatory cytokine levels. (C) 2015 Published by Elsevier B.V.

引用

页码：71 / 75

页数：5

共 21 条

[1]

Overexpression of phosphodiesterases in experimental autoimmune myasthenia gravis: suppression of disease by a phosphodiesterase inhibitor [J].