Time-related effects of stress on cholinergic sensitivity

被引：12

作者：

Pullia, D

DAmato, FR

Mele, A

Oliverio, A

Zocchi, A

Pavone, F

机构：

[1] CNR,IST PSICOBIOL & PSICOFARMACOL,I-00198 ROME,ITALY

[2] UNIV ROMA LA SAPIENZA,DIPARTIMENTO GENET & BIOL MOL,ROME,ITALY

[3] NIMH,BIOL PSYCHIAT BRANCH,NIH,BETHESDA,MD 20892

来源：

BRAIN RESEARCH | 1996年 / 743卷 / 1-2期

关键词：

restraint; oxotremorine; locomotor activity; acetylcholine; muscarinic receptor; prefrontal cortex; DBA/2; mice;

D O I：

10.1016/S0006-8993(96)00799-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the administration of the muscarinic cholinergic agonist oxotremorine on locomotor activity was investigated in DBA/2 mice subjected to chronic restraint stress of different durations (120 min daily for 10, 14 or 18 days). Oxotremorine induced a depressant effect on locomotion, which was reduced after 10 and 14 days of restraint, but not after a 18-day restraint stress. Acetylcholine (ACh) content was significantly reduced in prefrontal cortex after 10 and 14 days of stress but returned to control values after 18 days of restraint. No changes in ACh content were observed in nucleus accumbens and striatum. These results are discussed in terms of possible changes in muscarinic receptor sensitivity.

引用

页码：333 / 336

页数：4

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