Cancer Cell Metabolism

被引：122

作者：

Cairns, R. A. ^{[1
]}

Harris, I. ^{[1
,2
]}

McCracken, S. ^{[1
]}

Mak, T. W. ^{[1
]}

机构：

[1] Campbell Family Inst Breast Canc Res, Toronto, ON M5C2M9, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G2C1, Canada

来源：

METABOLISM AND DISEASE | 2011年 / 76卷

基金：

加拿大健康研究院;

关键词：

UNFOLDED PROTEIN RESPONSE; HYPOTHALAMIC MALONYL-COA; PYRUVATE-KINASE M2; INDUCIBLE FACTOR-I; TUMOR-SUPPRESSOR; GROWTH-FACTOR; GLUTAMINE-METABOLISM; AEROBIC GLYCOLYSIS; TRANSFORMED-CELLS; OXIDATIVE-STRESS;

D O I：

10.1101/sqb.2011.76.012856

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although the generation of a distinctive metabolic profile is a well-known aspect of cancer, the significance of these adaptations and their potential for exploitation for anticancer therapy has not been fully appreciated until recently. Many oncogenic changes known to affect intracellular signaling pathways play an active role in mediating these metabolic changes, which, in turn, function to support cancer cell growth and replication. In this chapter, we discuss the most current findings in cancer cell metabolism in terms of their impact on tumor cell growth as well as their potential for identifying new targets for therapeutic intervention.

引用

页码：299 / 311

页数：13

共 167 条

[1] DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway [J].

Aleyasin, Hossein ;

Rousseaux, Maxime W. C. ;

Marcogliese, Paul C. ;

Hewitt, Sarah J. ;

Irrcher, Isabella ;

Joselin, Alvin P. ;

Parsanejad, Mohammad ;

Kim, Raymond H. ;

Rizzu, Patrizia ;

Callaghan, Steve M. ;

Slack, Ruth S. ;

Mak, Tak W. ;

Park, David S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (07) :3186-3191

[2] OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells [J].

Almeida, R ;

Almeida, J ;

Shoshkes, M ;

Mendes, N ;

Mesquita, P ;

Silva, E ;

Van Seuningen, I ;

Reis, CA ;

Santos-Silva, F ;

David, L .

JOURNAL OF PATHOLOGY, 2005, 207 (04) :396-401

[3] Epidermal growth factor (EGF)-induced generation of hydrogen peroxide - Role in EGF receptor-mediated tyrosine phosphorylation [J].

Bae, YS ;

Kang, SW ;

Seo, MS ;

Baines, IC ;

Tekle, E ;

Chock, PB ;

Rhee, SG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (01) :217-221

[4] Parkinson's disease and cancer risk: a systematic review and meta-analysis [J].

Bajaj, Archna ;

Driver, Jane A. ;

Schernhammer, Eva S. .

CANCER CAUSES & CONTROL, 2010, 21 (05) :697-707

[5] Mitochondrial regulation of oxygen sensing [J].

Bell, EL ;

Emerling, BM ;

Chandel, NS .

MITOCHONDRION, 2005, 5 (05) :322-332

[6] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[7] HYPOXIA AND METABOLISM SERIES - TIMELINE The impact of O2 availability on human cancer [J].

Bertout, Jessica A. ;

Patel, Shetal A. ;

Simon, M. Celeste .

NATURE REVIEWS CANCER, 2008, 8 (12) :967-975

[8] IDH1 Mutations at Residue p.R132 (IDH1R132) Occur Frequently in High-Grade Gliomas But Not in Other Solid Tumors [J].

Bleeker, Fonnet E. ;

Lamba, Simona ;

Leenstra, Sieger ;

Troost, Dirk ;

Hulsebos, Theo ;

Vandertop, W. Peter ;

Frattini, Milo ;

Molinari, Francesca ;

Knowles, Margaret ;

Cerrato, Aniello ;

Rodolfo, Monica ;

Scarpa, Aldo ;

Felicioni, Lara ;

Buttitta, Fiamma ;

Malatesta, Sara ;

Marchetti, Antonio ;

Bardelli, Alberto .

HUMAN MUTATION, 2009, 30 (01) :7-11

[9] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor [J].

Brunet, A ;

Bonni, A ;

Zigmond, MJ ;

Lin, MZ ;

Juo, P ;

Hu, LS ;

Anderson, MJ ;

Arden, KC ;

Blenis, J ;

Greenberg, ME .

CELL, 1999, 96 (06) :857-868

[10] Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD [J].

Budanov, AV ;

Sablina, AA ;

Feinstein, E ;

Koonin, EV ;

Chumakov, PM .

SCIENCE, 2004, 304 (5670) :596-600

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