Electrochemically Initiated Tandem and Sequential Conjugate Addition Processes: One-Pot Synthesis of Diverse Functionalized Isoindolinones

被引：43

作者：

Antico, Pasqualmorica ^{[1
]}

Capaccio, Vito ^{[1
]}

Di Mola, Antonia ^{[2
]}

Massa, Antonio ^{[1
]}

Palombi, Laura ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Chim & Biol, I-84084 Fisciano, Sa, Italy

[2] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, Sa, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 09期

关键词：

electrosynthesis; hemiaminals; isoindolinones; one-pot Michael addition; tandem reactions; DYNAMIC COMBINATORIAL RESOLUTION; 3-SUBSTITUTED ISOINDOLINONES; ORGANIC ELECTROSYNTHESIS; ACETOACETIC DERIVATIVES; SUPPORTING ELECTROLYTE; DOMINO REACTIONS; CONDENSATION; GENERATION; SALICYLALDEHYDES; REARRANGEMENT;

D O I：

10.1002/adsc.201200065

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

A tandem aldolheterocyclizationrearrangement reaction and one-pot sequential Michael addition allowed a direct access to highly functionalized 3-isoindolinones containing quaternary carbon centers. The desired products are obtained under mild conditions and in short reaction times by galvanostatic electrolysis in a divided cell. A further tandem intramolecular heterocyclization reaction leading to synthetically relevant hemiaminal derivatives has been established with suitable Michael acceptors.

引用

收藏

页码：1717 / 1724

页数：8

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