Does structural neuroimaging reveal a disturbance of iron metabolism in Parkinson's disease? Implications from MRI and TCS studies

被引：37

作者：

Groeger, Adriane ^{[1
,2
]}

Berg, Daniela ^{[1
,2
]}

机构：

[1] Univ Tubingen, Dept Neurodegenerat, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

[2] Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, D-72076 Tubingen, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2012年 / 119卷 / 12期

关键词：

Parkinson's disease; Substantia nigra; Magnetic resonance imaging; Transcranial sonography; MULTIPLE SYSTEM ATROPHY; SUBSTANTIA-NIGRA; BRAIN IRON; TRANSCRANIAL SONOGRAPHY; SUSCEPTIBILITY; DEPOSITION; HYPERECHOGENICITY; ULTRASOUND; ECHOGENICITY; DISORDERS;

D O I：

10.1007/s00702-012-0873-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

A central role of iron in the pathogenesis of Parkinson's disease (PD) has been discussed for many years. Numerous studies using magnetic resonance imaging and transcranial sonography have been performed to detect alterations in tissue iron content of the substantia nigra. This manuscript reviews the findings of this still controversial issue and indicates that specific abnormalities that are suggested to be related to a disturbance of iron homeostasis may play an early role in the pathogenesis of PD.

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页码：1523 / 1528

页数：6

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