Role of nucleoporin induction in releasing an mRNA nuclear export block

被引：133

作者：

Enninga, J

Levy, DE

Blobel, G ^{[1
]}

Fontoura, BMA

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, Cell Biol Lab, New York, NY 10021 USA

[2] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[3] NYU, Sch Med, Kaplan Comprehens Canc Ctr, New York, NY 10016 USA

[4] Univ Miami, Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33136 USA

[5] Univ Miami, Sch Med, Sylvester Canc Ctr, Miami, FL 33136 USA

来源：

SCIENCE | 2002年 / 295卷 / 5559期

关键词：

D O I：

10.1126/science.1067861

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC). Some NPC components, such as the nucleoporins (Nups) Nup98 and Nup96, are also associated with the nuclear interior. Nup98 is a target of the vesicular stomatitis virus (VSV) matrix (M) protein-mediated inhibition of messenger RNA (mRNA) nuclear export. Here, Nup98 and Nup96 were found to be up-regulated by interferon (IFN). M protein-mediated inhibition of mRNA nuclear export was reversed when cells were treated with IFN-gamma or transfected with a complementary DNA (cDNA) encoding Nup98 and Nup96. Thus, increased Nup98 and Nup96 expression constitutes an IFN-mediated mechanism that reverses M protein-mediated inhibition of gene expression.

引用

收藏

页码：1523 / 1525

页数：3

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