Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

被引：562

作者：

Casanova-Acebes, Maria ^{[1
]}

Pitaval, Christophe ^{[1
]}

Weiss, Linnea A. ^{[1
]}

Nombela-Arrieta, Cesar ^{[2
]}

Chevre, Raphael ^{[1
]}

A-Gonzalez, Noelia ^{[1
]}

Kunisaki, Yuya ^{[3
]}

Zhang, Dachuan ^{[3
]}

van Rooijen, Nico ^{[4
]}

Silberstein, Leslie E. ^{[2
]}

Weber, Christian ^{[5
]}

Nagasawa, Takashi ^{[6
,7
,8
]}

Frenette, Paul S. ^{[3
]}

Castrillo, Antonio ^{[9
,10
]}

Hidalgo, Andres ^{[1
]}

机构：

[1] Fdn Ctr Nacl Invest Cardiovasc CNIC, Dept Epidemiol Atherothrombosis & Imaging, Madrid 28029, Spain

[2] Childrens Hosp, Joint Program Transfus Med, Boston, MA 02115 USA

[3] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[4] Vrije Univ Amsterdam, VUMC, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands

[5] Univ Munich, Inst Cardiovasc Prevent, D-80539 Munich, Germany

[6] Kyoto Univ, Core Res Evolut Sci & Technol CREST, Kyoto 6068507, Japan

[7] Kyoto Univ, Dept Immunobiol & Hematol, Inst Frontier Med Sci, Kyoto 6068507, Japan

[8] Japan Sci & Technol Agcy JST, Kyoto 6068507, Japan

[9] UAM Madrid, CSIC, Inst Invest Biomed Alberto Sols, Las Palmas Gran Canaria 35016, Spain

[10] Univ Las Palmas, CSIC, Unidad Asociada Biomed IIBM, Las Palmas Gran Canaria 35016, Spain

来源：

CELL | 2013年 / 153卷 / 05期

关键词：

STEM-CELL NICHE; BONE-MARROW; G-CSF; PROGENITOR CELLS; P-SELECTIN; INFLAMMATION; CXCR4; MOBILIZATION; RELEASE; MICE;

D O I：

10.1016/j.cell.2013.04.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow. We identify a population of CD62L(LO) CXCR4(HI) neutrophils that have "aged'' in the circulation and are eliminated at the end of the resting period in mice. Aged neutrophils infiltrate the bone marrow and promote reductions in the size and function of the hematopoietic niche. Modulation of the niche depends on macrophages and activation of cholesterol-sensing nuclear receptors and is essential for the rhythmic egress of hematopoietic progenitors into the circulation. Our results unveil a process that synchronizes immune and hematopoietic rhythms and expand the ascribed functions of neutrophils beyond inflammation.

引用

页码：1025 / 1035

页数：11

共 50 条

[1] Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR [J].

A-Gonzalez, Noelia ;

Bensinger, Steven J. ;

Hong, Cynthia ;

Beceiro, Susana ;

Bradley, Michelle N. ;

Zelcer, Noam ;

Deniz, Jose ;

Ramirez, Cristina ;

Diaz, Mercedes ;

Gallardo, German ;

Ruiz de Galarreta, Carlos ;

Salazar, Jon ;

Lopez, Felix ;

Edwards, Peter ;

Parks, John ;

Andujar, Miguel ;

Tontonoz, Peter ;

Castrillo, Antonio .

IMMUNITY, 2009, 31 (02) :245-258

[2] Therapeutic targeting of a stem cell niche [J].

Adams, Gregor B. ;

Martin, Roderick P. ;

Alley, Ian R. ;

Chabner, Karissa T. ;

Cohen, Kenneth S. ;

Calvi, Laura M. ;

Kronenberg, Henry M. ;

Scadden, David T. .

NATURE BIOTECHNOLOGY, 2007, 25 (02) :238-243

[3] Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation [J].

Basu, S ;

Hodgson, G ;

Katz, M ;

Dunn, AR .

BLOOD, 2002, 100 (03) :854-861

[4] Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist [J].

Broxmeyer, HE ;

Orschell, CM ;

Clapp, DW ;

Hangoc, G ;

Cooper, S ;

Plett, PA ;

Liles, WC ;

Li, XX ;

Graham-Evans, B ;

Campbell, TB ;

Calandra, G ;

Bridger, G ;

Dale, DC ;

Srour, EF .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (08) :1307-1318

[5] Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR [J].

Calkin, Anna C. ;

Tontonoz, Peter .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (04) :213-224

[6] Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

[7] Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche [J].

Chow, Andrew ;

Lucas, Daniel ;

Hidalgo, Andres ;

Mendez-Ferrer, Simon ;

Hashimoto, Daigo ;

Scheiermann, Christoph ;

Battista, Michela ;

Leboeuf, Marylene ;

Prophete, Colette ;

van Rooijen, Nico ;

Tanaka, Masato ;

Merad, Miriam ;

Frenette, Paul S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (02) :261-271

[8] Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines [J].

Collins, JL ;

Fivush, AM ;

Watson, MA ;

Galardi, CM ;

Lewis, MC ;

Moore, LB ;

Parks, DJ ;

Wilson, JG ;

Tippin, TK ;

Binz, JG ;

Plunket, KD ;

Morgan, DG ;

Beaudet, EJ ;

Whitney, KD ;

Kliewer, SA ;

Willson, TM .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (10) :1963-1966

[9] Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation [J].

Dibbert, B ;

Weber, M ;

Nikolaizik, WH ;

Vogt, P ;

Schöni, MH ;

Blaser, K ;

Simon, HU .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) :13330-13335

[10] Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches [J].

Ding, Lei ;

Morrison, Sean J. .

NATURE, 2013, 495 (7440) :231-235

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