Enzyme Directed Templating of Artificial Bone Mineral

被引：156

作者：

Spoerke, Erik D. ^{[1
]}

Anthony, Shown G. ^{[1
]}

Stupp, Samuel I. ^{[1
,2
,3
,4
]}

机构：

[1] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Inst Bionanotechnol Med, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Med, Evanston, IL 60208 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 04期

基金：

美国能源部;

关键词：

PEPTIDE-AMPHIPHILE NANOFIBERS; HYDROXYAPATITE FORMATION; PHOSPHOPROTEINS; NUCLEATION; MATRIX; ORGANOAPATITES; PHOSPHOPHORYN; SCAFFOLDS; SEQUENCES; IMPLANTS;

D O I：

10.1002/adma.200802242

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An artificial, in vitro biomineralization process that utilizes a nanofiber gel to as a substrate for biomimetic hydroxyapatite mineralization in three dimensions is presented. The system employs the natural enzyme alkaline phosphatase and a phosphorylated, anionic nanofiber gel matrix to template hydroxyapatite nano-crystals with size, shape, and crystallographic orientation resembling natural bone mineral.

引用

页码：425 / +

页数：7

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