The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis

被引：137

作者：

Yaniv, K ^{[1
]}

Yisraeli, JK ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Anat & Cell Biol, IL-91121 Jerusalem, Israel

来源：

GENE | 2002年 / 287卷 / 1-2期

关键词：

intracellular RNA localization; cell motility; metastasis;

D O I：

10.1016/S0378-1119(01)00866-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Vg1 RBP is a member of a family of highly conserved proteins that appear to be involved in RNA localization, stability, and/or translational control in a wide variety of cell types and organisms. Over the last few years, the human homologs of these proteins have been found to be overexpressed in an increasing number of different kinds of cancers. Although the role of these proteins in neoplasia is not understood, results from several labs, including our own, are beginning to suggest that many of these proteins may be important in cell motility, a necessary requirement for metastasis. This paper will review these data and suggest a model for the role of Vg1 RBP and its homologs in embryonic development and carcinogenesis. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：49 / 54

页数：6

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