New concepts in the generation and functions of IgA

被引：512

作者：

Pabst, Oliver ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Immunol, D-30625 Hannover, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 12期

关键词：

ISOLATED LYMPHOID FOLLICLES; IMMUNOGLOBULIN-A GENERATION; CLASS SWITCH RECOMBINATION; TISSUE-INDUCER CELLS; DENDRITIC CELLS; B-CELLS; PLASMA-CELLS; SOMATIC HYPERMUTATION; INTESTINAL BACTERIA; EPITHELIAL-CELLS;

D O I：

10.1038/nri3322

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intestinal mucosa contains the largest population of antibody-secreting plasma cells in the body, and in humans several grams of secretory immunoglobulin A (SIgA) are released into the intestine each day. In the gut lumen, SIgA serves as a first-line barrier that protects the epithelium from pathogens and toxins. Recently, next-generation sequencing has revolutionized our understanding of the nature of the intestinal microbiota and has also shed new light on the important roles of SIgA in the regulation of host-commensal homeostasis. Here, I discuss pathways of IgA induction in the context of SIgA specificity and function.

引用

页码：821 / 832

页数：12

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