RNAi:: nature abhors a double-strand

被引：367

作者：

Hutvágner, G ^{[1
]}

Zamore, PD ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01655 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(02)00290-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.

引用

页码：225 / 232

页数：8

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