RNAi:: nature abhors a double-strand

被引：367

作者：

Hutvágner, G ^{[1
]}

Zamore, PD ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01655 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(02)00290-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.

引用

页码：225 / 232

页数：8

共 70 条

[51] ATP requirements and small interfering RNA structure in the RNA interference pathway [J].

Nykänen, A ;

Haley, B ;

Zamore, PD .

CELL, 2001, 107 (03) :309-321

[52] Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference [J].

Parrish, S ;

Fleenor, J ;

Xu, SQ ;

Mello, C ;

Fire, A .

MOLECULAR CELL, 2000, 6 (05) :1077-1087

[53]

Parrish S, 2001, RNA, V7, P1397

[54]

Ray A, 1996, DEVELOPMENT, V122, P2631

[55] Maternal effects of the short integument mutation on embryo development in Arabidopsis [J].

Ray, S ;

Golden, T ;

Ray, A .

DEVELOPMENTAL BIOLOGY, 1996, 180 (01) :365-369

[56] Control of developmental timing in animals [J].

Rougvie, AE .

NATURE REVIEWS GENETICS, 2001, 2 (09) :690-701

[57]

Schmidt A, 1999, GENETICS, V151, P749

[58] On the role of RNA amplification in dsRNA-triggered gene silencing [J].

Sijen, T ;

Fleenor, J ;

Simmer, F ;

Thijssen, KL ;

Parrish, S ;

Timmons, L ;

Plasterk, RHA ;

Fire, A .

CELL, 2001, 107 (04) :465-476

[59] EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C-elegans [J].

Smardon, A ;

Spoerke, JM ;

Stacey, SC ;

Klein, ME ;

Mackin, N ;

Maine, EM .

CURRENT BIOLOGY, 2000, 10 (04) :169-178

[60] Gene expression - Total silencing by intron-spliced hairpin RNAs [J].

Smith, NA ;

Singh, SP ;

Wang, MB ;

Stoutjesdijk, PA ;

Green, AG ;

Waterhouse, PM .

NATURE, 2000, 407 (6802) :319-320

← 1 2 3 4 5 6 7 →