New insights into human enteric neuropathies

被引：61

作者：

De Giorgio, R ^{[1
]}

Guerrini, S ^{[1
]}

Barbara, G ^{[1
]}

Cremon, C ^{[1
]}

Stanghellini, V ^{[1
]}

Corinaldesi, R ^{[1
]}

机构：

[1] Univ Bologna, Dept Internal Med & Gastroenterol, Bologna, Italy

来源：

NEUROGASTROENTEROLOGY AND MOTILITY | 2004年 / 16卷

关键词：

achalasia; chronic constipation; chronic intestinal pseudo-obstruction; enteric nervous system; Hirschsprung's disease; human enteric neuropathies; neuronal degeneration;

D O I：

10.1111/j.1743-3150.2004.00491.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The functioning of enteric neuronal circuitries has been elucidated in the recent past. Evidence is now gathering to explain how dysfunction of the enteric nervous system (ENS) may lead to human gastrointestinal motor disorders. These conditions include achalasia, congenital hypertrophic pyloric stenosis, chronic intestinal pseudo-obstruction, Hirschsprung's disease, chronic idiopathic constipation, and probably irritable bowel syndrome. Degenerative, inflammatory and genetic mechanisms exert a critical role in ENS dysfunction underlying gut dysmotility. The study of the ENS abnormalities in gut dysmotility provides a framework to better understand the mechanisms involved in degeneration and neuronal loss and fosters the development of targeted therapeutic options.

引用

页码：143 / 147

页数：5

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