Studies directed toward the synthesis of ulapualide A: Phosphorus-based olefination as model studies for (Schlosser-like) fragment coupling

被引：19

作者：

Celatka, CA ^{[1
]}

Liu, P ^{[1
]}

Panek, JS ^{[1
]}

机构：

[1] BOSTON UNIV,METCALF CTR SCI & ENGN,DEPT CHEM,BOSTON,MA 02215

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 31期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)01219-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preliminary studies aimed at developing reaction conditions for the fragment coupling between the C-26-C-42 fragment and the tris-oxazole fragment of ulapualide A are described. Our approach utilizes Schlosser-Wittig olefination conditions for the construction of a trans-double bond. In this study, seven different tri-alkyl and tri-aryl phosphines were evaluated in an attempt to determine the extent of trans / cis selectivity for the prospective construction of the trans-C-25-C-26 double bond of ulapualide A. (C) 1997 Elsevier Science Ltd.

引用

页码：5449 / 5452

页数：4

共 15 条

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