Direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with ketones by use of the combination of amines and acids

被引：13

作者：

Funabiki, Kazumasa ^{[1
]}

Nagaya, Hideyuki ^{[1
]}

Ishihara, Mika ^{[1
]}

Matsui, Masaki ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Mat Sci & Technol, Gifu 5011193, Japan

来源：

TETRAHEDRON | 2006年 / 62卷 / 21期

关键词：

trifluoromethyl group; aldol reaction;

D O I：

10.1016/j.tet.2006.03.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trifluoroacetaldehyde ethyl hemiacetal reacts with unmodified ketones in the presence of 30-50 each moll % of amines and acids at ambient temperature, affording the corresponding beta-hydroxy-beta-trifluorornethylatcd ketones in good yields with good to excellent dia-stereoselectivities. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5049 / 5053

页数：5

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