Stereoselective Synthesis of Dienyl-Carboxylate Building Blocks: Formal Synthesis of Inthomycin C

被引：45

作者：

Souris, Caroline ^{[1
]}

Frebault, Frederic ^{[1
]}

Patel, Ashay ^{[2
]}

Audisio, Davide ^{[1
]}

Houk, K. N. ^{[2
]}

Maulide, Nuno ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 13期

关键词：

SMALL-MOLECULE SYNTHESIS; CYCLOBUTENE ELECTROCYCLIC REACTIONS; ASYMMETRIC ALLYLIC ALKYLATION; OXIDATION-WITTIG REACTIONS; CROSS-COUPLING REACTIONS; ORGANOBORON COMPOUNDS; VERSATILE; (+)-INTHOMYCIN-B; OXAZOLOMYCIN; COMPETITION;

D O I：

10.1021/ol401226y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct synthesis of stereodefined halodienes is reported. Those key building blocks enable a concise access to polyenic products, as demonstrated in a modular synthesis of Inthomycin C.

引用

页码：3242 / 3245

页数：4

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