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Regulatory role of cytokines in disseminated intravascular coagulation

被引：115
作者：
van der Poll, T
de Jonge, E
Levi, M
机构：
[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Intens Care Med, NL-1105 AZ Amsterdam, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands
来源：
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2001年 / 27卷 / 06期
关键词：
cytokines; endotoxin; coagulation; fibrinolysis; protein C;
D O I：
10.1055/s-2001-18868
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Disseminated intravascular coagulation (DIC) can complicate a number of diseases. DIC in the setting of sepsis is considered to result from strong activation of the coagulation system and concurrent inhibition of fibrinolysis and other anticoagulant pathways. Cytokines have been implicated as important mediators in these hemostatic alterations. This article summarizes recent insights into which cytokines are likely to be involved in the procoagulant response to systemic infection.
引用
收藏
页码：639 / 651
页数：13
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