Per-6-amino-β-cyclodextrin/CuI catalysed cyanation of aryl halides with K4[Fe(CN)6]

被引：32

作者：

Azath, Ismail Abulkalam ^{[1
]}

Suresh, Palaniswamy ^{[1
]}

Pitchumani, Kasi ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India

来源：

NEW JOURNAL OF CHEMISTRY | 2012年 / 36卷 / 11期

关键词：

BETA-CYCLODEXTRIN; CHIRAL RECOGNITION; AMINO-ACIDS; PALLADIUM; SYSTEM; BROMIDES; LIGAND; DERIVATIVES; CONVENIENT; COMPLEXES;

D O I：

10.1039/c2nj40556c

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Efficient cyanation of aryl halides is achieved using less toxic K-4[Fe(CN)(6)] as the reagent and amino-beta-cyclodextrins as supramolecular ligands for CuI. Four different amino cyclodextrins viz. per-6-amino-beta-CD, per-6-methylamino-beta-CD, per-6-butyl-amino-beta-CD and mono-6-amino-beta-CD are prepared and studied. Aryl and heteroaryl nitriles are obtained in good to excellent yield for even bromo derivatives of flavone and 2-aminopyrans. This system uses catalytic amounts (10 mol%) of both copper iodide and per-6-amino-beta-cyclodextrin. Easy separation, the absence of nitrogen atmosphere and excellent yield are the other significant outcomes of this protocol.

引用

页码：2334 / 2339

页数：6

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