Shared KEGG pathways of icariin-targeted genes and osteoarthritis

被引：17

作者：

Liu, Yi ^{[1
]}

Mi, Bobin ^{[1
,3
]}

Lv, Huijuan ^{[2
]}

Liu, Jing ^{[1
]}

Xiong, Yuan ^{[1
]}

Hu, Liangcong ^{[1
]}

Xue, Hang ^{[1
]}

Panayi, Adriana C. ^{[3
]}

Liu, Guohui ^{[1
]}

Zhou, Wu ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Orthopaed, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China

[2] Fourth Mil Med Univ, Dept Rheumatol, Tangdu Hosp, Xian, Shaanxi, Peoples R China

[3] Harvard Med Sch, Dept Plast Surg, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 05期

关键词：

bioinformatics analysis; chondrocytes; icariin; KEGG pathways; osteoarthritis (OA); NF-KAPPA-B; INFLAMMATORY RESPONSE; INSULIN-RESISTANCE; SIGNALING PATHWAY; CHONDROCYTES; APOPTOSIS; AUTOPHAGY; CARTILAGE; MICROSPHERES; INHIBITION;

D O I：

10.1002/jcb.28048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The beneficial effects of icariin in the management of many diseases, such as chronic renal failure and heart failure, are well known. Icariin has also been shown to ameliorate osteoarthritis (OA) symptoms; however, the underlying mechanisms remain unclear. In this study, a bioinformatics analysis was performed to investigate the KEGG pathways of icariin-targeted genes involved in OA. Our study suggests that icariin plays a role in OA by regulating inflammatory cytokine production, insulin resistance, and cell survival through modulation of the NF-kappa B, MAPK, and Akt signaling pathways. Importantly, IKBKB, NFKBIA, MAPK8, MAPK9, and MAPK10 may be the hub genes affected by icariin when providing its beneficial effects on OA. In addition, we found that icariin decreases proinflammatory factors and inhibits chondrocyte apoptosis through suppression of the NF-kappa B pathway. Our study highlights a set of KEGG pathways that could explain the molecular mechanism of icariin's action on OA, suggesting that icariin could be considered as a promising therapeutic option for OA.

引用

页码：7741 / 7750

页数：10

共 45 条

[1]

Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model [J].