The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis

被引：139

作者：

Chang, Jun ^{[1
]}

Wang, Wei ^{[1
]}

Zhang, Hui ^{[1
]}

Hu, Yong ^{[1
]}

Wang, Mingli ^{[2
]}

Yin, Zongsheng ^{[1
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Anhui Geriatr Inst, Dept Orthopaed, Hefei 230022, Anhui, Peoples R China

[2] Anhui Med Univ, Dept Microbiol, Hefei 230022, Anhui, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2013年 / 32卷 / 06期

关键词：

autophagy; osteoarthritis; chondrocyte; pathogenesis; aging; CELL-DEATH; MECHANISM; INDUCTION; RADIATION; APOPTOSIS;

D O I：

10.3892/ijmm.2013.1520

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we found that the expression of autophagy-related proteins was not decreased in the tissues of patients with OA. We also observed that rapamycin-induced autophagy prevented the accumulation of subdiploid cells in young chondrocytes, while it induced cell death by autophagy in OA chondrocytes. Our results demonstrate that autophagic activity decreases with aging, and may be responsible for the cytoprotective effects in young cartilage. However, we found that autophagic activity in patients with OA was higher than in the aging group, and reported autophagic cell death in OA chondrocytes. These results suggest that autophagy plays both a cytoprotective and death-promoting role in the pathogenesis of OA.

引用

页码：1311 / 1318

页数：8

共 41 条

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