Metabolic pattern formation in the tumor microenvironment

被引：8

作者：

Dai, Ziwei ^{[1
]}

Locasale, Jason W. ^{[1
]}

机构：

[1] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC 27708 USA

来源：

MOLECULAR SYSTEMS BIOLOGY | 2017年 / 13卷 / 02期

关键词：

CANCER; CELLS; WNT;

D O I：

10.15252/msb.20167518

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction-diffusion mechanism and is consistent with a Turing-type model of spatial localization.

引用

页数：2

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