Fundamentals of cancer metabolism

被引：2435

作者：

DeBerardinis, Ralph J. ^{[1
]}

Chandel, Navdeep S. ^{[2
]}

机构：

[1] Univ Texas Southwestern Med Ctr, Res Inst, Childrens Med Ctr, Dallas, TX 75390 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

来源：

SCIENCE ADVANCES | 2016年 / 2卷 / 05期

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; CELL LUNG-CANCER; OXIDATIVE-PHOSPHORYLATION; REDUCTIVE CARBOXYLATION; GLUTAMINE-METABOLISM; ALPHA-KETOGLUTARATE; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; L-2-HYDROXYGLUTARIC ACIDURIA; PYRUVATE CARBOXYLATION; LACTATE-DEHYDROGENASE;

D O I：

10.1126/sciadv.1600200

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.

引用

页数：18

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