Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

被引：139

作者：

Andronesi, Ovidiu C. ^{[1
]}

Rapalino, Otto ^{[2
]}

Gerstner, Elizabeth ^{[3
,4
]}

Chi, Andrew ^{[3
,4
]}

Batchelor, Tracy T. ^{[3
,4
,5
]}

Cahil, Dan P. ^{[6
]}

Sorensen, A. Gregory ^{[7
]}

Rosen, Bruce R. ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA USA

[2] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Neurooncol, Boston, MA USA

[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiat Oncol, Boston, MA USA

[6] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurosurg, Boston, MA USA

[7] Siemens Healthcare USA, Malvern, PA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 09期

关键词：

ACUTE MYELOID-LEUKEMIA; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; BRAIN-TUMORS; METABOLIC PROFILES; MR SPECTROSCOPY; SUFFICIENT; BIOMARKER; INSIGHTS; PULSES; ACID;

D O I：

10.1172/JCI67229

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic resonance spectroscopy (MRS) is well suited to the task of noninvasive D-2HG detection, and there has been much interest in developing such methods. Here, we review recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research.

引用

页码：3659 / 3663

页数：5

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