Asymmetric synthesis of cis-(-)-(2R4S)-4-(phosphonomethyl)-2-piperidinecarboxylic acid, a potent NMDA receptor antagonist

被引：64

作者：

Skiles, JW

Giannousis, PP

Fales, KR

机构：

[1] Ciba, Pharmaceuticals Division, Summit, NJ 07901

[2] Wayne State University, Department of Chemistry, Detroit

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 08期

关键词：

D O I：

10.1016/0960-894X(96)00150-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The asymmetric synthesis of cis-(-)-(2R4S)-4-(phosphononomethyl)-2-piperidinecarboxylic acid (1), a potent and specific NMDA receptor antagonist, via an olefin-iminium cyclization is described. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：963 / 966

页数：4

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