Phenolics with anti-HSV and anti-HIV activities from Artocarpus gomezianus , Mallotus pallidus , and Triphasia trifolia

被引：32

作者：

Likhitwitayawuid, K ^{[1
]}

Supudompol, B

Sritularak, B

Lipipun, V

Rapp, K

Schinazi, RF

机构：

[1] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok, Thailand

[3] Emory Univ, Sch Med, Vet Affairs Med Ctr, Decatur, GA 30033 USA

[4] Emory Univ, Sch Med, Dept Pediat, Decatur, GA 30033 USA

来源：

PHARMACEUTICAL BIOLOGY | 2005年 / 43卷 / 08期

关键词：

Artocarpus gomezianus; bis-hydroxyphenyl; coumarin; flavonoid; herpes; HIV; Mallotus pallidus; phenolic; phloroglucinol; Triphasia trifolia;

D O I：

10.1080/13880200500383058

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A total of 25 phenolic compounds were studied for their inhibitory effects against herpes simplex virus (HSV)-1, HSV-2, and human immunodeficiency virus (HIV)-1. These include five flavonoids (1-5) and two dimeric stilbenes (6,7) from Artocarpus gomezianus Wall. ex trec., five phloroglucinol derivatives (8-12) from Mallotus pallidus (Airy Shaw) Airy Shaw, and 13 courmarins (13-25) from Triphasia trifolia (Burm.f.) P. Wilson. The data obtained in this study suggest the bis-hydroxyphenyl structure as a potential target for anti-HSV and HIV drugs development.

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页码：651 / 657

页数：7

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