Glutamatergic synapses onto hippocampal interneurons: precision timing without lasting plasticity

被引:89
作者
McBain, CJ [1 ]
Freund, TE
Mody, I
机构
[1] NICHD, Lab Cellular & Mol Neurophysiol, Bethesda, MD 20892 USA
[2] Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary
[3] Univ Calif Los Angeles, Sch Med, Dept Neurol RNRC 3 131, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/S0166-2236(98)01347-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the hippocampal formation GABAergic inhibitory interneurons have a major role in the synchronization of neuronal activity and are involved in the generation of large-scale network oscillations. hus, interneurons function as a 'clock' that dictates when principal cells fire during suprathreshold excitatory drive. Interneurons receive strong excitatory innervation from glutamatergic neurons and it has been much debated whether these synapses show mechanisms of long-term plasticity similar to those found at principal-cell synapses. Recent findings support the lack of conventional forms of LTP and LTD in most interneurons, partly owing to the distinct anatomical and neurochemical features of interneuronal excitatory synapses. The uncommon properties of excitatory synapses on interneurons might be required for their functioning as accurate and reliable neuronal oscillators.
引用
收藏
页码:228 / 235
页数:8
相关论文
共 62 条
[31]   Differential signaling via the same axon of neocortical pyramidal neurons [J].
Markram, H ;
Wang, Y ;
Tsodyks, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :5323-5328
[32]   The calcineurin inhibitor cyclosporin A cyclophilin A complex reduces desensitization of GABA(A)-mediated responses in acutely dissociated rat hippocampal neurons [J].
Martina, M ;
Mozrzymas, JW ;
Boddeke, HWGM ;
Cherubini, E .
NEUROSCIENCE LETTERS, 1996, 215 (02) :95-98
[33]   Functional differences in Na+ channel gating between fast-spiking interneurones and principal neurones of rat hippocampus [J].
Martina, M ;
Jonas, P .
JOURNAL OF PHYSIOLOGY-LONDON, 1997, 505 (03) :593-603
[34]   Synaptic plasticity in hippocampal interneurons? A commentary [J].
McBain, CJ ;
Maccaferri, G .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1997, 75 (05) :488-494
[35]   Hippocampal interneurons express a novel form of synaptic plasticity [J].
McMahon, LL ;
Kauer, JA .
NEURON, 1997, 18 (02) :295-305
[36]   LATENT SYNAPTIC PATHWAYS REVEALED AFTER TETANIC STIMULATION IN THE HIPPOCAMPUS [J].
MILES, R ;
WONG, RKS .
NATURE, 1987, 329 (6141) :724-726
[37]  
MISGELD U, 1979, EXP BRAIN RES, V37, P217
[38]   MECHANISMS UNDERLYING INDUCTION OF HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF THE HIPPOCAMPUS [J].
MULKEY, RM ;
MALENKA, RC .
NEURON, 1992, 9 (05) :967-975
[39]   HETEROSYNAPTIC INTERACTIONS BETWEEN LTP AND LTD IN CA1 HIPPOCAMPAL SLICES [J].
MULLER, D ;
HEFFT, S ;
FIGUROV, A .
NEURON, 1995, 14 (03) :599-605
[40]   DENDRITIC SPINES AS INDIVIDUAL NEURONAL COMPARTMENTS FOR SYNAPTIC CA2+ RESPONSES [J].
MULLER, W ;
CONNOR, JA .
NATURE, 1991, 354 (6348) :73-76