Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus

被引：51

作者：

Alrubaian, J

Danielson, P

Fitzpatrick, M

Schreck, C

Dores, RM ^{[1
]}

机构：

[1] Univ Denver, Dept Biol Sci, Denver, CO 80208 USA

[2] Oregon State Univ, Oregon Cooperat Fishery Res Unit, Corvallis, OR 97331 USA

来源：

PEPTIDES | 1999年 / 20卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0196-9781(99)00021-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent study on the pituitary of the sturgeon, Acipenser transmontanus, resulted in the cloning of a cDNA that codes for the prohormone, proopiomelanocortin (POMC). This cDNA is designated sturgeon POMC A. Subsequent analysis of the sturgeon pituitary uncovered a second distinct POMC cDNA (sturgeon POMC B). In both sturgeon POMC cDNAs the open reading frame is 795 nucleotides in length. However, the two sturgeon POMC cDNAs differ at 26 amino acid positions in the opening frame. In addition, the 2 forms of POMC differ at 45 nucleotide positions within the open reading frame. The number and types of point mutations are compared in the 2 sturgeons POMC cDNAs, and the origin of the two POMC genes is discussed. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：431 / 436

页数：6

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