Efficient nucleophilic substitution reactions of pyrimidyl and pyrazyl halides with nucleophiles, under focused microwave irradiation

被引：50

作者：

Cherng, YH ^{[1
]}

机构：

[1] Chung Tai Inst Hlth Sci & Technol, Dept Med Technol, Taichung 40605, Taiwan

来源：

TETRAHEDRON | 2002年 / 58卷 / 05期

关键词：

microwave irradiation; nucleophilic substitution; halopyrimidines; chloropyrazine;

D O I：

10.1016/S0040-4020(01)01182-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rapid nucleophilic displacement reactions of 2-chloropyrimidine, 2-bromopyrimidine, 5-bromopyrimidine and chloropyrazine with nucleophiles under microwave irradiation was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to the classical heating processes. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：887 / 890

页数：4

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