Computational protein design

被引：145

作者：

Street, AG

Mayo, SL

机构：

[1] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

[3] CALTECH, Div Phys Math & Astron, Pasadena, CA 91125 USA

来源：

STRUCTURE | 1999年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0969-2126(99)80062-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 'protein design cycle', involving cycling between theory and experiment, has led to recent advances in rational protein design, A reductionist approach, in which protein positions are classified by their local environments, has aided development of an appropriate energy expression. The computational principles and practicalities of the protein design cycle are discussed.

引用

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页码：R105 / R109

页数：5

相关论文

共 60 条

[1] THE ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4-LYSOZYME [J].

BALDWIN, EP ;

HAJISEYEDJAVADI, O ;

BAASE, WA ;

MATTHEWS, BW .

SCIENCE, 1993, 262 (5140) :1715-1718

[2] DE-NOVO PROTEIN DESIGN - FROM MOLTEN GLOBULES TO NATIVE-LIKE STATES [J].

BETZ, SF ;

RALEIGH, DP ;

DEGRADO, WF .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (04) :601-610

[3] Formation and stability of β-hairpin structures in polypeptides [J].

Blanco, F ;

Ramírez-Alvarado, M ;

Serrano, L .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1998, 8 (01) :107-111

[4] PROTEIN DESIGN - A HIERARCHICAL APPROACH [J].

BRYSON, JW ;

BETZ, SF ;

LU, HS ;

SUICH, DJ ;

ZHOU, HXX ;

ONEIL, KT ;

DEGRADO, WF .

SCIENCE, 1995, 270 (5238) :935-941

[5]

CHAKRABARTTY A, 1994, PROTEIN SCI, V3, P843

[6] Optimizing potentials for the inverse protein folding problem [J].

Chiu, TL ;

Goldstein, RA .

PROTEIN ENGINEERING, 1998, 11 (09) :749-752

[7] Protein design automation [J].

Dahiyat, BI ;

Mayo, SL .

PROTEIN SCIENCE, 1996, 5 (05) :895-903

[8] Probing the role of packing specificity in protein design [J].

Dahiyat, BI ;

Mayo, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10172-10177

[9] Automated design of the surface positions of protein helices [J].

Dahiyat, BI ;

Gordon, DB ;

Mayo, SL .

PROTEIN SCIENCE, 1997, 6 (06) :1333-1337

[10] De novo protein design: Fully automated sequence selection [J].

Dahiyat, BI ;

Mayo, SL .

SCIENCE, 1997, 278 (5335) :82-87

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