Extracellular Signal-regulated Kinase 5 (ERK5) Mediates Prolactin-stimulated Adult Neurogenesis in the Subventricular Zone and Olfactory Bulb

被引：31

作者：

Wang, Wenbin ^{[1
]}

Pan, Yung-Wei ^{[2
]}

Wietecha, Tomasz ^{[3
]}

Zou, Junhui ^{[1
]}

Abel, Glen M. ^{[1
]}

Kuo, Chay T. ^{[4
,5
]}

Xia, Zhengui ^{[1
,2
]}

机构：

[1] Univ Washington, Toxicol Program, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[2] Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[4] Duke Univ, Dept Cell Biol, Durham, NC 27710 USA

[5] Duke Univ, Dept Pediat, Durham, NC 27710 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2013年 / 288卷 / 04期

基金：

美国国家卫生研究院;

关键词：

TARGETED DELETION; MAP KINASE; SURVIVAL; EXPRESSION; BRAIN; NEUROTROPHINS; INTERNEURONS; ACTIVATION; INHIBITORS; SECRETION;

D O I：

10.1074/jbc.M112.401091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prolactin-stimulated adult neurogenesis in the subventricular zone (SVZ) and olfactory bulb (OB) mediates several reproductive behaviors including mating/pregnancy, dominant male pheromone preference in females, and paternal recognition of offspring. However, downstream signaling mechanisms underlying prolactin-induced adult neurogenesis are completely unknown. We report here for the first time that prolactin activates extracellular signal-regulated kinase 5 (ERK5), a MAP kinase that is specifically expressed in the neurogenic regions of the adult mouse brain. Knockdown of ERK5 by retroviral infection of shRNA attenuates prolactin-stimulated neurogenesis in SVZ-derived adult neural stem/progenitor cells (aNPCs). Inducible erk5 deletion in adult neural stem cells of transgenic mice inhibits neurogenesis in the SVZ and OB following prolactin infusion or mating/pregnancy. These results identify ERK5 as a novel and critical signaling mechanism underlying prolactin-induced adult neurogenesis.

引用

页码：2623 / 2631

页数：9

共 36 条

[1] PATTERN OF PLASMA PROLACTIN CONCENTRATION DURING FIRST HALF OF MOUSE GESTATION [J].

BARKLEY, MS ;

BRADFORD, GE ;

GESCHWIND, II .

BIOLOGY OF REPRODUCTION, 1978, 19 (02) :291-296

[2] Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors [J].

Breton-Provencher, Vincent ;

Lemasson, Morgane ;

Peralta, Modesto R., III ;

Saghatelyan, Armen .

JOURNAL OF NEUROSCIENCE, 2009, 29 (48) :15245-15257

[3] Transient expression of doublecortin during adult neurogenesis [J].

Brown, JP ;

Couillard-Després, S ;

Cooper-Kuhn, CM ;

Winkler, J ;

Aigner, L ;

Kuhn, HG .

JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 467 (01) :1-10

[4] Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons [J].

Cavanaugh, JE ;

Ham, J ;

Hetman, M ;

Poser, S ;

Yan, C ;

Xia, ZG .

JOURNAL OF NEUROSCIENCE, 2001, 21 (02) :434-443

[5] ERK5 MAP Kinase Regulates Neurogenin1 during Cortical Neurogenesis [J].

Cundiff, Paige ;

Liu, Lidong ;

Wang, Yupeng ;

Zou, Junhui ;

Pan, Yung-Wei ;

Abel, Glen ;

Duan, Xin ;

Ming, Guo-Li ;

Englund, Chris ;

Hevner, Robert ;

Xia, Zhengui .

PLOS ONE, 2009, 4 (04)

[6] ISOLATION OF MEK5 AND DIFFERENTIAL EXPRESSION OF ALTERNATIVELY SPLICED FORMS [J].

ENGLISH, JM ;

VANDERBILT, CA ;

XU, SC ;

MARCUS, S ;

COBB, MH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (48) :28897-28902

[7] Coitus-induced orgasm stimulates prolactin secretion in healthy subjects [J].

Exton, MS ;

Krüger, THC ;

Koch, M ;

Paulson, E ;

Knapp, W ;

Hartmann, U ;

Schedlowski, M .

PSYCHONEUROENDOCRINOLOGY, 2001, 26 (03) :287-294

[8] Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5 [J].

Finegan, K. G. ;

Wang, X. ;

Lee, E-J ;

Robinson, A. C. ;

Tournier, C. .

CELL DEATH AND DIFFERENTIATION, 2009, 16 (05) :674-683

[9] Prolactin: structure, function, and regulation of secretion [J].

Freeman, ME ;

Kanyicska, B ;

Lerant, A ;

Nagy, G .

PHYSIOLOGICAL REVIEWS, 2000, 80 (04) :1523-1631

[10] Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor [J].

Kato, Y ;

Tapping, RI ;

Huang, S ;

Watson, MH ;

Ulevitch, RJ ;

Lee, JD .

NATURE, 1998, 395 (6703) :713-716

← 1 2 3 4 →