Extracellular Signal-regulated Kinase 5 (ERK5) Mediates Prolactin-stimulated Adult Neurogenesis in the Subventricular Zone and Olfactory Bulb

被引：31

作者：

Wang, Wenbin ^{[1
]}

Pan, Yung-Wei ^{[2
]}

Wietecha, Tomasz ^{[3
]}

Zou, Junhui ^{[1
]}

Abel, Glen M. ^{[1
]}

Kuo, Chay T. ^{[4
,5
]}

Xia, Zhengui ^{[1
,2
]}

机构：

[1] Univ Washington, Toxicol Program, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[2] Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[4] Duke Univ, Dept Cell Biol, Durham, NC 27710 USA

[5] Duke Univ, Dept Pediat, Durham, NC 27710 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2013年 / 288卷 / 04期

基金：

美国国家卫生研究院;

关键词：

TARGETED DELETION; MAP KINASE; SURVIVAL; EXPRESSION; BRAIN; NEUROTROPHINS; INTERNEURONS; ACTIVATION; INHIBITORS; SECRETION;

D O I：

10.1074/jbc.M112.401091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prolactin-stimulated adult neurogenesis in the subventricular zone (SVZ) and olfactory bulb (OB) mediates several reproductive behaviors including mating/pregnancy, dominant male pheromone preference in females, and paternal recognition of offspring. However, downstream signaling mechanisms underlying prolactin-induced adult neurogenesis are completely unknown. We report here for the first time that prolactin activates extracellular signal-regulated kinase 5 (ERK5), a MAP kinase that is specifically expressed in the neurogenic regions of the adult mouse brain. Knockdown of ERK5 by retroviral infection of shRNA attenuates prolactin-stimulated neurogenesis in SVZ-derived adult neural stem/progenitor cells (aNPCs). Inducible erk5 deletion in adult neural stem cells of transgenic mice inhibits neurogenesis in the SVZ and OB following prolactin infusion or mating/pregnancy. These results identify ERK5 as a novel and critical signaling mechanism underlying prolactin-induced adult neurogenesis.

引用

页码：2623 / 2631

页数：9

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